Geringer, Scott A.; Singh, Yashapal; Hoard, Daniel J.; Demchenko, Alexei V. published the artcile< A Highly Efficient Glycosidation of Glycosyl Chlorides by Using Cooperative Silver(I) Oxide-Triflic Acid Catalysis>, Synthetic Route of 4064-06-6, the main research area is cooperative silver catalyzed glycosidation benzoyl benzyl protected glycosyl chloride; activation; carbohydrates; glycosyl chlorides; glycosylation; silver oxide.
Following our discovery that silver(I) oxide-promoted glycosylation with glycosyl bromides can be greatly accelerated in the presence of catalytic TMSOTf or TfOH, we report herein a new discovery that glycosyl chlorides are even more effective glycosyl donors under these reaction conditions. The developed reaction conditions work well with a variety of glycosyl chlorides. Both benzoylated and benzylated chlorides have been successfully glycosidated, and these reaction conditions proved to be effective in coupling substrates containing nitrogen and sulfur atoms. Another convenient feature of this glycosylation is that the progress of the reaction can be monitored visually; its completion can be judged by the disappearance of the characteristic dark color of Ag2O.
Chemistry – A European Journal published new progress about Benzoyl group (protecting). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.
Referemce:
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