Wang, Jiao; Fan, Xiuju; Feng, Xiao; Li, Yueming published an article on February 28 ,1993. The article was titled 《Studies on enantioselective effect of chiral titanate reagents on the synthesis of substituted benzhydrols》, and you may find the article in Chemical Research in Chinese Universities.Recommanded Product: 63012-03-3 The information in the text is summarized as follows:
Chiral titanate reagents were prepared for use in the asym. synthesis of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature, and exchange of reactants by crossing experiments were investigated. Favored attack of the nucleophile upon the prochiral face of the aromatic aldehyde is proposed, the absolute configurations of the resulting benzhydrols are suggested, and a preliminary reaction mechanism is described. Thus, PhMgBr reacted with 3-ClC6H4CHO in Et2O in the presence of the (+)-tartarate-titanate I to give (-)-(R)-PhCH(OH)C6H4Cl-3 in 34% enantiomeric excess, in contrast, similar reaction of 3-ClC6H4MgBr with PhCHO in the presence of (+)-I gave (+)-(S)-PhCH(OH)C6H4Cl-3 in 73% enantiomeric excess. In addition to this study using (3-Chlorophenyl)(phenyl)methanol, there are many other studies that have used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Recommanded Product: 63012-03-3) was used in this study.
(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Recommanded Product: 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts