Fallica, Antonino Nicolo; Barbaraci, Carla; Amata, Emanuele; Pasquinucci, Lorella; Turnaturi, Rita; Dichiara, Maria; Intagliata, Sebastiano; Gariboldi, Marzia Bruna; Marras, Emanuela; Orlandi, Viviana Teresa; Ferroni, Claudia; Martini, Cecilia; Rescifina, Antonio; Gentile, Davide; Varchi, Greta; Marrazzo, Agostino published an article in 2021. The article was titled 《Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3-Aminopropan-1-ol The information in the text is summarized as follows:
The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability to interfere with DNA topoisomerase II. We herein envisioned the design and synthesis of novel Ciprofloxacin and Norfloxacin nitric oxide (NO) photo-donor hybrids to explore the potential synergistic antitumor effect exerted by the fluoroquinolone scaffold and NO eventually produced upon light irradiation Anticancer activity, evaluated on a panel of tumor cell lines, showed encouraging results with IC50 values in the low micromolar range. Some compounds displayed intense antiproliferative activity on triple-neg. and doxorubicin-resistant breast cancer cell lines, paving the way for their potential use to treat aggressive, refractory and multidrug-resistant breast cancer. No significant additive effect was observed on PC3 and DU145 cells following NO release. Conversely, antimicrobial photodynamic experiments on both Gram-neg. and Gram-pos. microorganisms displayed a significant killing rate in Staphylococcus aureus, accounting for their potential effectiveness as selective antimicrobial photosensitizers. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 3-Aminopropan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts