《Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles》 was written by Li, Chengxi; Zhang, Yuanyuan; Sun, Qi; Gu, Tongnian; Peng, Henian; Tang, Wenjun. Electric Literature of C8H9ClO2 And the article was included in Journal of the American Chemical Society on August 31 ,2016. The article conveys some information:
We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. For example, reacting PhCH(Br)Me with (E)-4-MeC6H4CH:CHB(OH)2 in K3PO4/toluene under nitrogen at 80°C for 4 h gave (E)-4-MeC6H4CH:CHCH(Me)Ph in 73% yield. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp2)-C(sp3) cross-coupling. The experimental process involved the reaction of (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Electric Literature of C8H9ClO2)
(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Electric Literature of C8H9ClO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts