Sashidhara, Koneni V.; Kumar, Manoj; Khedgikar, Vikram; Kushwaha, Priyanka; Modukuri, Ram K.; Kumar, Abdhesh; Gautam, Jyoti; Singh, Divya; Sridhar, Balasubramaniam; Trivedi, Ritu published an article on January 10 ,2013. The article was titled 《Discovery of Coumarin-Dihydropyridine Hybrids as Bone Anabolic Agents》, and you may find the article in Journal of Medicinal Chemistry.SDS of cas: 153759-59-2 The information in the text is summarized as follows:
The concept of mol. hybridization led us to discover a novel series of coumarin-dihydropyridine hybrids that have potent osteoblastic bone formation in vitro and that prevent ovariectomy-induced bone loss in vivo. In this context, among all the compounds screened for alk. phosphatase activity, four compounds 10, 14, 18, and 22 showed significant activity at picomolar concentrations A series of other in vitro data strongly suggested compound 18 as the most promising bone anabolic agent, which was further evaluated for in vivo studies. From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass d. and volume, expression of osteogenic genes (RUNX2, BMP-2, and ColI), bone formation rate (BFR), and mineral apposition rate (MAR), improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2SDS of cas: 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.SDS of cas: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
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