The author of 《Photoinduced Proton-Transfer Reactions for Mild O-H Functionalization of Unreactive Alcohols》 were Jana, Sripati; Yang, Zhen; Li, Fang; Empel, Claire; Ho, Junming; Koenigs, Rene M.. And the article was published in Angewandte Chemie, International Edition in 2020. Safety of 3,3,3-Trifluoropropan-1-ol The author mentioned the following in the article:
Hexafluoroisopropanol is typically considered as an unreactive solvent and not as a reagent in organic synthesis. Herein, we report on a mild and efficient photochem. reaction of aryl diazoacetates with hexafluoroisopropanol that enables, under stoichiometric reaction conditions, the synthesis of fluorinated ethers in excellent yield. Mechanistic studies indicate there is a preorganization of hexafluoroisopropanol and the diazoalkane acts as an unreactive hydrogen-bonding complex. Only after photoexcitation does this complex undergo a protonation-substitution reaction to the reaction product. Investigations on the applicability of this photochem. transformation show that a broad variety of acidic alcs. can be subjected to this transformation and thus demonstrate the feasibility of this concept for O-H functionalization reactions (54 examples, up to 98% yield). In the experimental materials used by the author, we found 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Safety of 3,3,3-Trifluoropropan-1-ol)
3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Safety of 3,3,3-Trifluoropropan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts