In 2017,Tan, Qiuyuan; Wang, Xinqiao; Xiong, Yang; Zhao, Zimeng; Li, Lu; Tang, Pei; Zhang, Min published 《Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers》.Angewandte Chemie, International Edition published the findings.Application of 126456-43-7 The information in the text is summarized as follows:
We have developed a highly efficient asym. allylboration of ketimines with nonchiral γ,γ-disubstituted allylboronic acids by using a chiral amino alc. as the directing group, which is otherwise challenging. The amino alc. not only serves as a cheap source of nitrogen and chirality, but also dramatically enhances the reactivity. The versatility of this method was demonstrated by its ability to access all four stereoisomers with adjacent quaternary carbon centers. A reaction model was proposed to explain the diastereoselectivity and the rate-accelerating effect. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application of 126456-43-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts