Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H11NO, blongs to alcohols-buliding-blocks compound. Formula: C4H11NO
THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.08271 mol) were added to the reaction vessel at 20-35¡ã C. The resulting slurry was heated to reflux (75-80¡ã C.) for 16-20 h. The reaction was cooled to 30-40¡ã C. and THF was evaporated at below 45¡ã C. under reduced pressure. The reaction mixture was cooled to 20-35¡ã C., rinsed with ethyl acetate and water, and the ethyl acetate layer was collected. The organic layer was concentrated under vacuum at below 45¡ã C. then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-10 h at 45-50¡ã C. under vacuum to provide 2-methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)-pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol.
The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Celgene Corporation; Agios Pharmaceuticals, Inc.; Bhat, Sreenivas S.; Burnside, Scott; Parikh, Darshan; Gu, Chong-Hui; Altaf, Syed; (34 pag.)US2018/64715; (2018); A1;,
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