In 2022,Xu, Haiting; Luo, Ruifeng; Dong, Lingling; Pu, Xiulan; Chen, Qiyan; Ye, Naijing; Qi, Shanshan; Han, Xiaoqin; Nie, Wenbiao; Fu, Chaomei; Hu, Yichen; Zhang, Jinming; Gao, Fei published an article in Nanomedicine (New York, NY, United States). The title of the article was 《pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis》.Formula: C4H11NO The author mentioned the following in the article:
An oral nanoparticle (NPs) encapsulated in chitosan/alginate hydrogel (CA-Gel) with dual-sensitive in pH and reactive oxygen species (ROS) was developed to load curcumin (CUR) based on the intracellular-specific characteristics of macrophages. Chondroitin sulfate (CS) wrapped PBAE-SA-PAPE with intracellular pH/ROS dual-sensitive characteristics and CUR via a simple nanopptn. method to form NPs (CS-CUR-NPs), and mixed CA-Gel to acquire the final preparation (CS-CUR-NPs-Gel). CS-CUR-NPs displayed an ideal average particle size (179.19 ± 5.61 nm) and high encapsulating efficiency (94.74 ± 1.15%). CS showed a good targeting ability on macrophages and the CA-Gel contribution in protecting NPs from being destroyed in the upper gastrointestinal tract. As expected, CS-CUR-NPs-Gel could significantly alleviate inflammation in DSS-induced UC mice via TLR4-MAPK/NF-ΚB pathway. This study is the first to attempt to design a novel pH/ROS dual-stimulated release strategy in helping intracellular CUR delivery and anticipated for efficient anti-UC therapy. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts