In 2019,European Journal of Organic Chemistry included an article by Kovalenko, Maksym; Yarmoliuk, Dmytro V.; Serhiichuk, Dmytro; Chernenko, Daria; Smyrnov, Vladyslav; Breslavskyi, Artur; Hryshchuk, Oleksandr V.; Kleban, Ihor; Rassukana, Yuliya; Tymtsunik, Andriy V.; Tolmachev, Andrey A.; Kuchkovska, Yuliya O.; Grygorenko, Oleksandr O.. Product Details of 78782-17-9. The article was titled 《The Boron-Wittig Olefination of Aldehydes and Ketones with Bis[(pinacolato)boryl]methane: an Extended Reaction Scope》. The information in the text is summarized as follows:
Aryl aldehydes and ketones R1R2C:O undergo borylative olefination with diborylmethane CH2(Bpin)2 affording vinylboronates R1R2C:CH(Bpin) (R1 = aryl, heterocyclyl, cyclopropyl, dioxolanyl, oxazolidinyl); cyclic and heterocyclic ketones were also olefinated giving borylmethylene-functionalized compounds Q:CHBpin (Q = azetidine, pyrrolidine, piperidine, carboxycyclobutane, carboxycyclopentane). Preparation of 2,2-disubstituted and 2-monosubstituted alkenylboronic acid esters from aliphatic and aromatic ketones and aldehydes by the boron-Wittig olefination with bis[(pinacolato)boryl]methane was examined and applied on the multigram scale. The influence of the substrate steric and electronic features on the overall efficiency and stereochem. outcome of the reaction was studied. Addnl., a series of diversely functionalized (hetera)cycloalkylidenemethyl and (hetera)cycloalkyl boronic acid-derived building blocks was synthesized. In the experiment, the researchers used many compounds, for example, Bis[(pinacolato)boryl]methane(cas: 78782-17-9Product Details of 78782-17-9)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Product Details of 78782-17-9
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