《Synthesis, in vitro evaluation, and molecular docking studies of benzofuran based hydrazone a new inhibitors of urease》 was written by Abdullah Al-Mohammadi, Jana; Taha, Muhammad; Rahim, Fazal; Hussain, Rafaqat; aldossary, Hanan; Khalid Farooq, Rai; Wadood, Abdul; Nawaz, Muhammad; Salahuddin, Mohammed; Mohammed Khan, Khalid; Uddin, Nizam. Product Details of 26153-38-8This research focused onurease inhibitor benzofuran hydrazone mol docking. The article conveys some information:
This work has described the synthesis of novel class (1-25) of benzofuran based hydrazone. The hybrid scaffolds (1-25) of benzofuran based hydrazone were evaluated in vitro, for their urease inhibition. All the newly synthesized analogs (1-25) were found to illustrate moderate to good urease inhibitory profile ranging from 0.20 ± 0.01 to 36.20 ± 0.70 μM. Among the series, compounds 22 (IC50 = 0.20 ± 0.01 μM), 5 (IC50 = 0.90 ± 0.01 μM), 23 (IC50 = 1.10 ± 0.01 μM) and 25 (IC50 = 1.60 ± 0.01 μM) were found to be the many folds more potent than thiourea as standard inhibitor (IC50 = 21.86 ± 0.40 μM). The elevated inhibitory profile of these analogs might be due to presence of dihydroxy and flouro groups at different position of Ph ring B attached to hydrazone skeleton. These dihydroxy and fluoro groups bearing compounds have shown many folds better inhibitory profile through involvement of oxygen of dihydroxy groups in hydrogen bonding with active site of enzymes. Various types of spectroscopic techniques such as 1H-, 13C- NMR and HREI-MS spectroscopy were used to confirm the structure of all the newly developed compounds To find SAR, mol. docking studies were performed to understand, the binding mode of potent inhibitors with active site of enzymes and results supported the exptl. data. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8
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