In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. Formula: C4H10O3
General procedure: Preparation of 2-(2-(trityloxyl)ethoxyl)ethanol 3a is used as an example. To a stirring solution ofdiethylene glycol 2a (34.4 g, 324.0 mmol), DMAP (1.3 g, 10.8 mmol) and triethylamine (18.7 mL,130.0 mmol) in CH2Cl2 (200 mL) at 40oC was slowly added a solution of triphenylmethyl chloride(30.1 g, 108.0 mmol) in CH2Cl2 (100 mL) over an hour. After the addition, the mixture was refluxed until no more triphenylmethyl chloride can be detected by TLC (usually 2-3h). Then, the mixture was cooled and poured into brine (300 mL), extracted with CH2Cl2 (150 mL, three times). The combined organic phase was dried over anhydrous Na2SO4, concentrated under vacuum, purified by flash chromatography on silica gel to give 3a as white wax (30.7 g, yield: 82%). 1H NMR (400MHz, CDCl3) delta 3.27 (t, J = 6.0 Hz, 2H), 3.61 (t, J = 4.0 Hz, 2H), 3.66-3.73 (m, 4H), 7.20-7.31 (m,9H), 7.45-7.47 (m, 6H).
The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Yu; Thapa, Bijaya; Zhang, Hua; Li, Xuefei; Yu, Fanghua; Jeong, Eun-Kee; Yang, Zhigang; Jiang, Zhong-Xing; Tetrahedron; vol. 69; 46; (2013); p. 9586 – 9590;,
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