Lemir, Ignacio D.; Oksdath-Mansilla, Gabriela; Castro-Godoy, Willber D.; Schmidt, Luciana C.; Arguello, Juan E. published an article in 2022. The article was titled 《Photochemical Csp2-H bond thiocyanation and selenocyanation of activated arenes, batch and continuous-flow approaches》, and you may find the article in Photochemical & Photobiological Sciences.Recommanded Product: Oxetan-3-ol The information in the text is summarized as follows:
An eco-friendly photochem. oxidative Csp2-H thiocyanation and selenocyanation of activated arenes were reported. The reaction proceeded under Violet LED irradiation in the presence of K2S2O8, which quickly oxidized KSCN and KSeCN, finally producing arylthio/selenocyanates. Using this benign, atom-economic protocol, the desired chalcogenide products were obtained regioselectively, with isolated yields that range from very good to excellent. Although, mechanistic study indicated that it is difficult to distinguish between a radical to a SEAr reaction mechanism between the photo-induced formed •SCN, for the former, or NCSSCN, for the latter, to the aromatic heterocycles. The inhibition experiment together with the observed reactivity and regioselectivity, would be in agreement with the latter. The synthetic methodol. designed could be successfully adapted to continuous-flow systems in a segmented-flow regime, employing the organic phase as the product reservoir. Using this setup, the advantage of the latter could be demonstrated by reducing the reaction time and improving the product yields. Similarly, the scaling up of the reaction to gram scale resulted in favorable outcomes by the flow setup, which installed the photo-flow chem. as a powerful tool to be included into routine reaction procedures, which had great relevance for the pharmaceutical industry.Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol) was used in this study.
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