Zhou, Lin; Lu, Runxin; Liu, Qijun; Xiao, Bin; Hai, Li; Guo, Li; Wu, Yong; Zheng, Yongxiang published an article on February 28 ,2021. The article was titled 《Two branched fructose modification improves tumor targeting delivery of liposomes to breast cancer in intro and in vivo》, and you may find the article in Journal of Drug Delivery Science and Technology.Formula: C12H20O6 The information in the text is summarized as follows:
Breast cancer is the leading cause of cancer death for females and needs more specific treatments. D-fructose is a promising ligand targeting to glucose transporter 5 (GLUT5) on breast cancer cells, and single-branched fructose has been used for targeting nanoparticles. However, the impact of two-branched fructose on targeting delivery remains to be elucidated. In this study, we synthesized a two-branched fructose ligand, prepared fructose-decorating liposomes and evaluated them in vitro and in vivo. The results showed liposomes were approx. 102 nm-107 nm in size, with -3.19 mV to -3.61 mV zeta potential, and their encapsulation efficiency of paclitaxel (PTX) were 87% ∼ 91%. The liposomes decorated with two-branched fructose (Fru2-Lip) had the highest cellular uptake and cytotoxicity in 4T1 cells and MCF7 cells in vitro, and the strongest in vivo targeting delivery and accumulation in breast tumor sites, even compared with the liposomes decorated with two equivalent fructose. Further investigation of the mechanism underlying the increased targeting released the two-branched fructose had a 7.93 kcal/mol higher binding free energy to GLUT5, compared with the single-branched fructose. These results illustrated the two-branched fructose can significantly enhance the tumor-targeting of liposomes and supported the application of multi-branched ligands for the design of tumor-specific targeting delivery system. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)
((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II). And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts