Choi, Seon-Hee; Lee, Dong-Yeon; Kang, Sohi; Lee, Min-Kyung; Lee, Jae-Heun; Lee, Sang-Heon; Lee, Hye-Lim; Lee, Hyo-Young; Jeong, Young-IL published their research in International Journal of Molecular Sciences in 2021. The article was titled 《Caffeic acid phenethyl ester-incorporated radio-sensitive nanoparticles of phenylboronic acid pinacol ester-conjugated hyaluronic acid for application in radioprotection》.COA of Formula: C12H17BO2 The article contains the following contents:
We synthesized phenylboronic acid pinacol ester (PBPE)-conjugated hyaluronic acid (HA) via thiobis(ethylamine) (TbEA) linkage (abbreviated as HAsPBPE conjugates) to fabricate the radiosensitive delivery of caffeic acid phenetyl ester (CAPE) and for application in radioprotection. PBPE was primarily conjugated with TbEA and then PBPE-TbEA conjugates were conjugated again with hyaluronic acid using carbodiimide chem. CAPE-incorporated nanoparticles of HAsPBPE were fabricated by the nanopptn. method and then the organic solvent was removed by dialysis. CAPE-incorporated HAsPBPE nanoparticles have a small particle size of about 80 or 100 nm and they have a spherical shape. When CAPE-incorporated HAsPBPE nanoparticles were irradiated, nanoparticles became swelled or disintegrated and their morphologies were changed. Furthermore, the CAPE release rate from HAsPBPE nanoparticles were increased according to the radiation dose, indicating that CAPE-incorporated HAsPBPE nanoparticles have radio-sensitivity. CAPE and CAPE-incorporated HAsPBPE nanoparticles appropriately prevented radiation-induced cell death and suppressed intracellular accumulation of reactive oxygen species (ROS). CAPE and CAPE-incorporated HAsPBPE nanoparticles efficiently improved survivability of mice from radiation-induced death and reduced apoptotic cell death. We suggest that HAsPBPE nanoparticles are promising candidates for the radio-sensitive delivery of CAPE.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6COA of Formula: C12H17BO2) was used in this study.
4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).COA of Formula: C12H17BO2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts