Kushwaha, Pragati; Tripathi, Ashish Kumar; Gupta, Sampa; Kothari, Priyanka; Upadhyay, Akanksha; Ahmad, Naseer; Sharma, Tanuj; Siddiqi, M. I.; Trivedi, Ritu; Sashidhara, Koneni V. published their research in European Journal of Medicinal Chemistry on August 5 ,2018. The article was titled 《Synthesis and study of benzofuran-pyran analogs as BMP-2 targeted osteogenic agents》.Application of 153759-59-2 The article contains the following contents:
Twenty-four novel benzofuran-pyran derivatives were synthesized and evaluated for their anti-osteoporotic activity in primary cultures of rat calvarial osteoblasts in vitro. Among all the compounds screened for the alk. phosphatase activity, three compounds 9-(2-(4-fluorobenzoyl)-7-methylbenzofuran-5-yl)3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione , 9-(7-Ethyl-2-(4-fluorobenzoyl)benzofuran-5-yl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione and 9-(7-Ethyl-2-(4-fluorobenzoyl)benzofuran-5-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione showed potent activity at picomolar concentrations in osteoblast differentiating stimulation. Addnl., these compounds were found effective in mineralization, assessed by alizarin red-S staining assay. Compounds were again validated through a series of other in vitro experiments Moreover, mol. dynamics simulations demonstrated that both benzofuran and pyran moieties are requisite to fit into the active site of BMP-2 receptor, a key target of the osteogenic agents. The obtained results strongly convey that compound 9-(2-(4-fluorobenzoyl)-7-methylbenzofuran-5-yl)3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione is a potential bone anabolic agent among synthesized series, which can be further explored as a drug lead for treating osteoporosis. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Application of 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Application of 153759-59-2
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