In 2019,Journal of Physics: Conference Series included an article by Aderohunmu, Damilola V.; Ajani, Olayinka O.; Oduselu, Gbolahan O.; Adebiyi, Ezekiel F.. Reference of 3-Hydroxybenzaldehyde. The article was titled 《Microwave-assisted synthesis of coumarin-based 5,6-dihydro pyrimidin-2(1H)-one derivatives》. The information in the text is summarized as follows:
Microwave assisted synthesis of novel coumarin-based 5,6-dihydropyrimidin-2(1H)-one derivatives was achieved via a three-step synthetic approach. The reaction was initiated with catalyst supported multicomponent reaction to produce 3-acetylcoumarin which upon condensation with five aromatic aldehydes furnished chalcones. Microwave assisted reaction of chalcones with lone pair donor and urea led to the formation of the targeted coumarin-based 5,6- dihydropyrimidin-2(1H)-ones in good-to-excellent yields. The structures were established using spectroscopic data and notable phys. properties and the results obtained were consistent with the expected structure of the products. The compounds were good for further study to authenticate their applications in drug design and material science research. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Reference of 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Reference of 3-Hydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts