《Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Panczyk, Katarzyna; Rapacz, Anna; Furgala-Wojas, Anna; Salat, Kinga; Koczurkiewicz-Adamczyk, Paulina; Lucjanek, Martyna; Skiba-Kurek, Iwona; Karczewska, Elzbieta; Sowa, Aleksandra; Zelaszczyk, Dorota; Siwek, Agata; Popiol, Justyna; Pekala, Elzbieta; Marona, Henryk; Waszkielewicz, Anna. Recommanded Product: trans-4-Aminocyclohexanol The article mentions the following:
As part of the presented research, thirteen new aminoalkanol derivatives were designed and obtained by chem. synthesis. In vivo studies (mice, i.p.) showed anticonvulsant activity (MES) of nine compounds, and in the case of one compound (R,S-trans-2-((2-(2,3,5-trimethylphenoxy)ethyl)amino)cyclohexan-1-ol, 4) both anticonvulsant (ED50 MES = 15.67 mg/kg, TD50 rotarod = 78.30 mg.kg, PI = 5.00) and analgesic activity (OXA-induced neuropathic pain, active at 15 mg/kg). For selected active compounds addnl. in vitro studies have been performed, including receptor studies (5-HT1A), evaluation of antioxidant activity (DPPH assay), metabolism studies as well as safety panel (mutagenicity, safety in relation to the gastrointestinal flora, cytotoxicity towards astrocytes as well as impact on their proliferation and cell cycle). In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: trans-4-Aminocyclohexanol)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Recommanded Product: trans-4-Aminocyclohexanol
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