In 2022,Hashimoto, Hisashi; Ueda, Yoshihiro; Takasu, Kiyosei; Kawabata, Takeo published an article in Angewandte Chemie, International Edition. The title of the article was 《Catalytic Substrate-Selective Silylation of Primary Alcohols via Remote Functional-Group Discrimination》.COA of Formula: C4H11NO The author mentioned the following in the article:
Silylation of alcs. has generally been known to take place at the sterically most accessible less-hindered hydroxy group. Herein, the catalyst-controlled substrate-selective silylation of primary alcs., in which the selectivity was controlled independently of the innate reactivity of the hydroxy group, based on the steric environment, is reported. The chain-length-selective silylation of 1,n-amino alc. derivatives was achieved and 1,5-amino alc. derivatives showed outstandingly high reactivity in the presence of analogs with a shorter or longer chain length under catalyst-controlled conditions. A highly substrate-selective catalytic silylation of pentanol analogs was also developed, in which the remote functionality at C(5) from the reacting hydroxy groups was effectively discriminated on silylation.4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO) was used in this study.
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts