Related Products of 627-18-9In 2021 ,《Synthesis of novel acyl derivatives of 3-(4,5,6,7-tetrabromo-1H-benzimidazol-1-yl)propan-1-ols-intracellular TBBi-based CK2 inhibitors with proapoptotic properties》 was published in International Journal of Molecular Sciences. The article was written by Chojnacki, Konrad; Winska, Patrycja; Karatsai, Olena; Koronkiewicz, Miroslawa; Milner-Krawczyk, Malgorzata; Wielechowska, Monika; Redowicz, Maria Jolanta; Bretner, Maria; Borowiecki, Pawel. The article contains the following contents:
Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy. The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their resp. esters was carried out by using chemoenzymic methods. Concomitantly with kinetic studies toward recombinant CK2, the influence of the obtained compounds on the viability of two human breast carcinoma cell lines (MCF-7 and MDA-MB-231) was evaluated using MTT assay. Addnl., an intracellular inhibition of CK2 as well as an induction of apoptosis in the examined cells after the treatment with the most active compounds were studied by Western blot anal., phase-contrast microscopy and flow cytometry method. The results of the MTT test revealed potent cytotoxic activities for most of the newly synthesized compounds (EC50 4.90 to 32.77 μM), corresponding to their solubility in biol. media. We concluded that derivatives with the Me group decrease the viability of both cell lines more efficiently than their non-methylated analogs. Furthermore, inhibition of CK2 in breast cancer cells treated with the tested compounds at the concentrations equal to their EC50 values correlates well with their lipophilicity since derivatives with higher values of logP are more potent intracellular inhibitors of CK2 with better proapoptotic properties than their parental hydroxyl compounds After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9)
3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Related Products of 627-18-9
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