Alachouzos, Georgios’s team published research in European Journal of Medicinal Chemistry in 2017 | CAS: 27489-62-9

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Safety of trans-4-Aminocyclohexanol

In 2017,Alachouzos, Georgios; Lenselink, Eelke B.; Mulder-Krieger, Thea; de Vries, Henk; IJzerman, Adriaan P.; Louvel, Julien published 《Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A1 receptor antagonists》.European Journal of Medicinal Chemistry published the findings.Safety of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Aminodiarylpyrimidines such as I were prepared as potential selective adenosine A1 receptor antagonists, based on a scaffold with high affinity for human adenosine A1 receptors but limited selectivity over adenosine A2a receptors. The effect of aryl structure and amino group substituents on adenosine A1 receptor antagonism and selectivity was determined I was identified as a potent (Ki(hA1AR) = 7.7 nM) and selective (Ki(hA2AAR) = 1389 nM) antagonist at the human adenosine A1 receptor; mol. docking calculations at adenosine A1 and A2a receptors were used to rationalize the effect of the 4-hydroxycyclohexyl substituent on selectivity and the nature of the pyrimidine substituents on affinity. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Safety of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Safety of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts