Synthetic Route of 702-82-9 , The common heterocyclic compound, 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 2(41 mg, 0.25 mmol) was dissolved in THF (15 ml). To the solution Et3N(69 mul, 0.50 mmol), indazole-3-carboxylic acid (27 mg, 0.16 mmol) and TBTU (79mg, 0.25 mmol) were added. The reaction mixture was left to stir overnight atroom temperature. Concentrated and purified on silica using a mobile phasesystem of EtOAc/n-heptane (4:1) to give compound 3 (41.5 mg, yield 81%).
The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wallgren, Jakob; Vikingsson, Svante; Johansson, Anders; Josefsson, Martin; Green, Henrik; Dahlen, Johan; Wu, Xiongyu; Konradsson, Peter; Tetrahedron Letters; vol. 58; 15; (2017); p. 1456 – 1458;,
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