In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2077-19-2
(2E)-3-(4-(1-Methyl-1H-pyrazol-4-yl)pyridin-3-yl)-N-phenylacrylamide A mixture of (2E)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)acrylamide (266 mg), 2-(4-bromophenyl)propan-2-ol (276 mg), Xantphos (67 mg), Pd2(dba)3 (53 mg), sodium tert-butoxide (157 mg) and toluene (5 mL) was stirred at 120 C. for 45 minutes under microwave irradiation. The reaction mixture was filtered through Celite, and water was added to the filtrate, followed by extraction with ethyl acetate. The organic layer was washed with brine and then dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to obtain (2E)-N-(4-(2-hydroxypropan-2-yl)phenyl)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)acrylamide (101 mg) and (2E)-3-(4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-N-phenylacrylamide (6 mg). 1H NMR (300 MHz, DMSO-d6) delta 1.41 (6H, s), 3.94 (3H, s), 4.94 (1H, s), 6.85 (1H, d, J=15.6 Hz), 7.42 (2H, d, J=8.7 Hz), 7.49 (1H, d, J=5.2 Hz), 7.62 (2H, d, J=8.7 Hz), 7.64-7.80 (2H, m), 8.08 (1H, s), 8.53 (1H, d, J=5.2 Hz), 8.77 (1H, s), 10.23 (1H, s). 1H NMR (300 MHz, DMSO-d6) delta 3.94 (3H, s), 6.86 (1H, d, J=15.7 Hz), 7.02-7.15 (1H, m), 7.35 (2H, t, J=7.9 Hz), 7.49 (1H, d, J=4.8 Hz), 7.66-7.80 (4H, m), 8.09 (1H, s), 8.53 (1H, d, J=5.2 Hz), 8.78 (1H, s), 10.29 (1H, s).
The synthetic route of 2077-19-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; HIRAYAMA, Takaharu; FUJIMOTO, Jun; CARY, Douglas Robert; OKANIWA, Masanori; HIRATA, Yasuhiro; (147 pag.)US2017/44132; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts