Anandan, Sampath-Kumar; Webb, Heather K.; Do, Zung N.; Gless, Richard D. published the artcile< Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble epoxide hydrolase>, Recommanded Product: 3-Aminocyclohexanol, the main research area is unsym aryl urea derivative preparation soluble epoxide hydrolase inhibitor; aryl amide derivative preparation soluble epoxide hydrolase inhibitor.
Incorporation of an adamantyl group in prototypical soluble epoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. Replacement of the adamantyl group in unsym. ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors, e.g., I and II, is explored. Aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded enzyme IC50 values comparable to the adamantyl compounds in an ether substituted, unsym. N,N’-diaryl urea or amide scaffold.
Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.
Referemce:
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Alcohols – Chemistry LibreTexts