Cheruku, Srinivas; Nagarakere, Sandhya C.; Sunilkumar, Makanahalli P.; Narayana, Yatheesh; Manikyanally, Kumara N.; Rangappa, Kanchugarakoppal S.; Mantelingu, Kempegowda published the artcile< An expedient, efficient and solvent-free synthesis of T3P-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation>, Category: alcohols-buliding-blocks, the main research area is amide sulfonamide carbamate preparation; benzhydrol amide amidation catalyst propylphosphonic anhydride; sulfonamide benzhydrol amidation catalyst propylphosphonic anhydride; carbamate benzhydrol amidation catalyst propylphosphonic anhydride.
An expedient, efficient, economical, environmentally benign and solvent free synthesis of amides, sulfonamides and carbamates I [R = CO2Me, Ms, C(O)Ph, etc.; R1 = Me, Ph, 4-FC6H4, 4-ClC6H4; R2 = H, 4-F, 4-Cl] via amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P) under microwave irradiation was developed. The methodol. was deployed for a wide range of heterocycles and electron-withdrawing and electron-donating groups. The protocol resulted in good to excellent yields of under the given conditions (68-93% yield).
New Journal of Chemistry published new progress about Amidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts