Maji, Ankur; Singh, Anshu; Singh, Neetu; Ghosh, Kaushik published the artcile< Efficient Organoruthenium Catalysts for α-Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is preparation quinoline organoruthenium catalyst; ketone alc alkylation; amino benzyl alc ketone cyclization; tertiary amide alc alkylation.
A new family of phosphine free organometallic ruthenium(II) catalysts supported by bidentate NN Schiff base ligands I (R = NMe2, NEt2) and II was prepared These half-sandwich complexes acted as catalysts for C-C bond formation and exhibited excellent performance in the dehydrogenative coupling of ketones and amides. In the synthesis of C-C bonds, alcs. were utilized as the alkylating agent. A broad range of substrates, including sterically hindered ketones and alcs., were well tolerated under the optimized conditions (TON up to 47000 and TOF up to 11750 h-1). This ruthenium (II) catalysts were also active towards the dehydrogenative cyclization of o-amino benzyl alc. for the formation of quinolines derivatives Various polysubstituted quinolines were synthesized in moderate to excellent yields (TON up to 71000 and TOF up to 11830 h-1). Control experiments were carried out and the ruthenium hydride intermediate was characterized to support the reaction mechanism and a probable reaction pathway of dehydrogenative coupling for the C-C bond formation has been proposed.
ChemCatChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts