Application of 3840-31-1, Adding some certain compound to certain chemical reactions, such as: 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3840-31-1.
Commercial available (3,4,5-trimethoxyphenyl)methanol (25 g, 126 mmol) was dissolved in THF (150 mL). Sodium hydride (3.93 g, 164 mmol) was added portionwise at 0C. The reaction mixture was stirred at 0C for 10 min. Then iodomethane (10.21 ml, 164 mmol) was added drop wise. The resultant mixture was stirred from 0C to rt for 3 hours and quenched by pouring into ice. The mixture was extracted with ethyl acetate, washed by brine and dried by anhydrous sodium sulfate. After filtered and concentrated, the afforded residue was purified by silica gel column. Colorless oil l,2,3-trimethoxy-5-(methoxymethyl)benzene (26.44 g, 125 mmol, 99 % yield) was afforded. 1H NMR (400 MHz, CDC13) delta 6.53 (s, 2H), 4.35 (s, 2H), 3.82 (s, 6H), 3.79 (s, 3H), 3.36 (s, 3H). 13C NMR (101 MHz, CDC13) delta 153.22 (2C), 137.36, 133.82, 104.53 (2C), 74.83, 60.76, 58.11, 56.02 (2C). ESI-MS m/z: 235.0 (MNa+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES; ZHAO, Xue, Zhi; HUGHES, Stephen, H.; VU, Bao-Han, Christie; SMITH, Steven; JOHNSON, Barry; POMMIER, Yves; BURKE, Terrence, R., Jr.; WO2013/16441; (2013); A1;,
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