Ibert, Quentin; Cauwel, Madeleine; Glachet, Thomas; Tite, Tony; Le Nahenec-Martel, Patricia; Lohier, Jean-Francois; Renard, Pierre-Yves; Franck, Xavier; Reboul, Vincent; Sabot, Cyrille published the artcile< One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight>, COA of Formula: C4H8N2O, the main research area is ketone aldehyde imine ammonia butyl hypochlorite phenyliodine diacetate cyclization; diazirine one pot preparation.
Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. In all cases, an inexpensive com. solution of ammonia (NH3) in methanol (MeOH) was employed, avoiding the difficult use of liquid ammonia. With aliphatic ketones, t-Bu hypochlorite (t-BuOCl) was found to be the best oxidant whereas it is preferable to use phenyliodine diacetate (PIDA) with aromatic ketones, aldehydes and imines. The nature of the imine-protecting group is essential and only t-Bu imine allowed the synthesis of 15N2-diazirine with complete 15N incorporation, emphasizing a key trans-imination step in the reaction mechanism. These methods are operationally simple, and tolerant to most functional groups, providing diazirines with yields ranging from 20 to 99%.
Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts