Adding a certain compound to certain chemical reactions, such as: 112-47-0, 1,10-Decanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 1,10-Decanediol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 1,10-Decanediol
Hydrobromic acid (1.2 mL 48% aqueous solution, 9.5 mmol) was added to a suspension of 1,10-decanediol 1 (1.5 g, 8.6 mmol) in 30 mL of toluene in a round-bottomed flask equipped with a Dean-Stark trap and a cooler. The mixture was refluxed for 16 h. After cooling, the solvent was removed under reduced pressure. The residue obtained was chromatographed on silica gel using hexane/ethyl acetate (8:2) to yield the pure compound 2 (Scheme 1). Yield 74%; yellow oily product: IR (KBr): v = 3325, 2925, 2850,1450, 1250, 1050, 700, 625, 550 cm-1. 1H NMR (200 MHz, CDCl3): delta1.20-1.40 (m, 12H), 1.45-1.60 (m, 2H), 1.84 (qn, J=6.8 Hz, 2H), 3.39 (t, J=6.8 Hz, 2H), 3.62 (t, J=6.4 Hz, 2H) ppm. 13C NMR (50 MHz, CDCl3) delta: 25.67, 28.11, 28.69, 29, 32, 29.42, 32.73, 32.77, 33.98, 62.99 ppm.
The synthetic route of 112-47-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guimaraes, Daniel Silqueira Martins; de Sousa Luz, Leticia Silveira; do Nascimento, Sara Batista; Silva, Lorena Rabelo; de Miranda Martins, Natalia Rezende; de Almeida, Heloisa Goncalves; de Souza Reis, Vitoria; Maluf, Sarah El Chamy; Budu, Alexandre; Marinho, Juliane Aparecida; Abramo, Clarice; Carmona, Adriana Karaoglanovic; da Silva, Marina Goulart; da Silva, Gisele Rodrigues; Kemmer, Victor Matheus; Butera, Anna Paola; Ribeiro-Viana, Renato Marcio; Gazarini, Marcos Leoni; Junior, Clebio Soares Nascimento; Guimaraes, Luciana; dos Santos, Fabio Vieira; de Castro, Whocely Victor; Viana, Gustavo Henrique Ribeiro; de Brito, Cristiana Ferreira Alves; de Pilla Varotti, Fernando; European Journal of Pharmaceutical Sciences; vol. 138; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts