Hess, Stephan N.; Mo, Xiaobin; Wirtz, Conny; Fuerstner, Alois published the artcile< Total Synthesis of Limaol>, Product Details of C4H8O, the main research area is limaol total synthesis Stille asym propargylation spirocyclization.
A nonthermodynamic array of four skipped methylene substituents on the hydrophobic tail renders limaol (I), a C40-polyketide of marine origin, unique in structural terms. This conspicuous segment was assembled by a two-directional approach and finally coupled to the polyether domain by an allyl/alkenyl Stille reaction under neutral conditions. The core region itself was prepared via a 3,3′-dibromo-BINOL-catalyzed asym. propargylation, a gold-catalyzed spirocyclization, and introduction of the southern sector via substrate-controlled allylation as the key steps.
Journal of the American Chemical Society published new progress about Diastereoselective synthesis. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts