Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji published the artcile< NNN pincer Ru(II)-catalyzed dehydrogenative coupling of 2-aminoarylmethanols with nitriles for the construction of quinazolines>, Name: (2-Aminophenyl)methanol, the main research area is aminobenzyl alc nitrile ruthenium catalyst oxidative coupling reaction; quinazoline preparation green chem.
An efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy was developed. Under the optimized conditions, a broad range of substituted o-aminobenzyl alcs. and (hetero)aryl or alkyl nitriles were well tolerated to afford various 2-substituted quinazolines in high yields. Subsequently, a set of control experiments was performed to elucidate the reaction mechanism, which underwent alc. oxidation, nitrile hydration and cyclocondensation steps. This protocol was featured with several advantages, such as environmental benignity, operational simplicity, broad substrate scope (compatible with aliphatic nitriles, up to 87% yield) and short reaction time (mostly in 2 h).
Tetrahedron published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.
Referemce:
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Alcohols – Chemistry LibreTexts