Zhang, Yanke; Yang, Sufen; Yang, Yang; Liu, Teng published the artcile< Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells>, Product Details of C14H12O3, the main research area is ovarian carcinoma resveratrol immunogenic cell death; Cytotoxic T cell; Immunogenic cell death; Ovarian carcinoma; Resveratrol.
Purpose: This study aimed to clarify whether immunogenic cell death (ICD) contributed to the anti-tumor action of resveratrol against ovarian carcinoma. Methods: Resveratrol suppressed cell proliferation and induced apoptosis in ovarian carcinoma cells. In addition, resveratrol treatment stimulated cell surface exposure of calreticulin, HMGB1 secretion and ATP release. Results: Vaccination with resveratrol-pretreated ID8 cells significantly inhibited growth of subsequent inoculated xenograft tumor. Direct administration with resveratrol suppressed tumor progression accompanied with compromised cell proliferation and enhanced cell apoptosis. We further characterized increases of both mature dendritic cells and cytotoxic T cells in xenograft tumor in response to resveratrol treatment, which also inhibited TGF-β production and stimulated both IL12p7 and IFN-γ secretion. Most importantly, we demonstrated that combination with PD-1 antibody greatly inhibited tumor growth, while depletion of CD8+ T cells by neutralizing antibody restored xenograft progression. Conclusion: Our data suggested resveratrol exerted anti-tumor action against ovarian cancer via both apoptosis and ICD pathways.
Infectious Agents and Cancer published new progress about CD8-positive T cell. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts