In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. Formula: C13H20O4
2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (1.0 g, 4.16 mmol) and carbon tetrabromide (1.40 g, 4.2 mmol) were dissolved in dichloromethane under an argon atmosphere. The flask was placed in a water bath and triphenylphosphine (1.10 g, 4.2 mmol) in dichloromethane (10 ml_) was added drop-wise over 15 minutes. After stirring for an additional 2 hours at room temperature, the solution was concentrated and the product was purified by flash column chromatography on silica gel (30 g), eluting with a mixture of heptanes/ethyl acetate (3:1 ). The experiment generated ((2-(2-(2- bromoethoxy)ethoxy)ethoxy)methyl)benzene 5 (1 .0 g, 80% yield) as a colorless liquid. 1H NMR (300 MHz, CDCI3): 7.60-7.40 (m, 5H), 4.56 (s, 2H), 3.79 (t, 2H, J = 6.3 Hz), 3.72-3.55 (m, 8H), 3.44 (t, 2H, J = 6.3 Hz). 13C (75 MHz, CDCI3): 138.24, 128.37, 127.74, 127.61 , 73.34, 71.32, 70.83, 70.76, 70.66, 69.55, 30.55.
The synthetic route of 55489-58-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RODOS BIOTARGET GMBH; AUGUSTUS BIOTARGET, INC.; SCOLARO, Michael, J.; SULLIVAN, Sean, M.; GIESELER, Robert, K.; HOZSA, Constantin; FURCH, Marcus; (68 pag.)WO2017/17148; (2017); A1;,
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