Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D. published the artcile< Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols>, Application of C8H9FO, the main research area is pyrimidine preparation; alc amidine multicomponent dehydrogenative coupling nickel catalyst.
Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways.
Asian Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application of C8H9FO.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts