Cordell, Geoffrey A. published the artcile< 2-Halopyrroles. Synthesis and chemistry>, SDS of cas: 52160-51-7, the main research area is halopyrrole; pyrrole halogenation; benzylbromopyrrole; bromopyrrole benzyl; chloropyrrole benzyl; stability halopyrrole; electrophilic substitution halopyrrole; formylation halopyrrole; diazo coupling halopyrrole.
Following the confirmation that both 2-chloropyrrole (I) and 2-bromopyrrole (II) were unstable species, a number of 1-alkyl and C-alkyl 2-halopyrroles were synthesized to investigate the range of instability. The 1-alkyl 2-halopyrroles synthesized were 2-chloro-1-methylpyrrole (III), 2-bromo-1-methylpyrrole, 1-benzyl-2-chloropyrrole, and 1-benzyl-2-bromopyrrole. The C-alkyl-2-halopyrroles synthesized were 5-chloro-2-methylpyrrole (IV), 2-tert-butyl-5-chloropyrrole, 5-chloro-2,3,4-trimethylpyrrole (V), and 5-bromo-2,3,4-trimethylpyrrole. Also synthesized were the 1-methyl derivatives of IV and V. Electrophilic substitution of I and II under the conditions for formylation and diazo coupling was examined In the case of the latter reaction no crystalline compounds could be isolated, but diazo coupling of III gave rise to exclusive α-substitution. Formylation of I gave the α-substituted derivative but II gave a product arising from the displacement of bromine, 5-chloropyrrole-2-carboxaldehyde, in addition to 5-bromopyrrole-2-carboxaldehyde.
Journal of Organic Chemistry published new progress about Coupling reaction. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, SDS of cas: 52160-51-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts