Bueno Duarte, Gustavo Henrique; de Piloto Fernandes, Anna Maria Alves; Silva, Alex Aparecido Rosini; Zamora-Obando, Hans R.; Amaral, Alan Goncalves; de Sousa Mesquita, Alessandra; Schmidt-Filho, Jayr; Cordeiro de Lima, Vladmir C.; D’Almeida Costa, Felipe; Andrade, Victor Piana; Porcari, Andreia M.; Eberlin, Marcos Nogueira; Simionato, Ana Valeria Colnaghi published the artcile< Gas chromatography-mass spectrometry untargeted profiling of non-Hodgkin's lymphoma urinary metabolite markers>, Formula: C6H10O8, the main research area is gas chromatog mass spectrometry non Hodgkin lymphoma metabolomic biomarker; Biomarkers; Gas chromatography-mass spectrometry; Metabolomics; Non-Hodgkin’s lymphoma.
Abstract: Non-Hodgkin’s lymphoma (NHL) is a cancer of the lymphatic system where the lymphoid and hematopoietic tissues are infiltrated by malignant neoplasms of B, T, and natural killer lymphocytes. Effective and less invasive methods for NHL screening are urgently needed. Herein, we report an untargeted gas chromatog.-mass spectrometry (GC-MS) method to investigate metabolic changes in non-volatile derivatized compounds from urine samples of NHL patients (N = 15) and compare them to healthy controls (N = 34). Uni- and multivariate data anal. showed 18 endogenous metabolites, including amino acids and their metabolites, sugars, small organic acids, and vitamins, as statistically significant for group differentiation. A receiver operating characteristic curve (ROC) generated from a support vector machine (SVM) algorithm-based model achieved 0.998 of predictive accuracy, displaying the potential and relevance of GC-MS-detected urinary non-volatile compounds for predictive purposes. Furthermore, a specific panel of key metabolites was also evaluated, showing similar results. All in all, our results indicate that this robust GC-MS method is an effective screening tool for NHL diagnosis and it is able to highlight different pathways of the disease.
Analytical and Bioanalytical Chemistry published new progress about Cancer diagnosis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.
Referemce:
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Alcohols – Chemistry LibreTexts