Ceballos, Francisco C.; Virseda-Berdices, Ana; Resino, Salvador; Ryan, Pablo; Martinez-Gonzalez, Oscar; Perez-Garcia, Felipe; Martin-Vicente, Maria; Brochado-Kith, Oscar; Blancas, Rafael; Bartolome-Sanchez, Sofia; Vidal-Alcantara, Erick Joan; Alboniga-Diez, Oihane Elena; Cuadros-Gonzalez, Juan; Blanca-Lopez, Natalia; Martinez, Isidoro; Martinez-Acitores, Ignacio Ramirez; Barbas, Coral; Fernandez-Rodriguez, Amanda; Jimenez-Sousa, Maria Angeles published the artcile< Metabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation>, Formula: C6H10O8, the main research area is metabolic profiling COVID 19 disease severity sex specific dysregulation; COVID-19; Spanish hospitals; disease onset; metabolomics; severity; sex-specific.
Metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression. We performed a retrospective cross-sectional study in 123 COVID-19 patients which were stratified as asymptomatic/mild, moderate and severe according to the highest COVID-19 severity status, and a group of healthy controls. We performed an untargeted plasma metabolic profiling (gas chromatog. and capillary electrophoresis-mass spectrometry (GC and CE-MS)) and cytokine evaluation. After data filtering and identification we observed 105 metabolites dysregulated (66 GC-MS and 40 CE-MS) which shown different expression patterns for each COVID-19 severity status. These metabolites belonged to different metabolic pathways including amino acid, energy, and nitrogen metabolism among others. Severity-specific metabolic dysregulation was observed, as an increased transformation of L-tryptophan into L-kynurenine. Thus, metabolic profiling at hospital admission differentiate between severe and moderate patients in the later phase of worse evolution. Several plasma pro-inflammatory biomarkers showed significant correlation with deregulated metabolites, specially with L-kynurenine and L-tryptophan. Finally, we describe a strong sex-related dysregulation of metabolites, cytokines and chemokines between severe and moderate patients. In conclusion, metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the SARS-CoV-2 mol. pathogenesis. This technique makes it possible to identify metabolic phenoconversion that predicts disease progression and explains the pronounced pathogenesis differences between sexes.
Frontiers in Immunology published new progress about COVID-19. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts