Yin, Shenyi; Xi, Ruibin; Wu, Aiwen; Wang, Shu; Li, Yingjie; Wang, Chaobin; Tang, Lei; Xia, Yuchao; Yang, Di; Li, Juan; Ye, Buqing; Yu, Ying; Wang, Junyi; Zhang, Hanshuo; Ren, Fei; Zhang, Yuanyuan; Shen, Danhua; Wang, Lin; Ying, Xiangji; Li, Zhongwu; Bu, Zhaode; Ji, Xin; Gao, Xiangyu; Jia, Yongning; Jia, Ziyu; Li, Nan; Li, Ziyu; Ji, Jia-Fu; Xi, Jianzhong Jeff published the artcile< Patient-derived tumor-like cell clusters for drug testing in cancer therapy>, Recommanded Product: Calcium folinate, the main research area is gastric colorectal breast cancer recurrence metastases.
Several patient-derived tumor models emerged recently as robust preclin. drug-testing platforms. However, their potential to guide clin. therapy remained unclear. Here, we report a model called patient-derived tumor-like cell clusters (PTCs). PTCs result from the self-assembly and proliferation of primary epithelial, fibroblast, and immune cells, which structurally and functionally recapitulate original tumors. PTCs enabled us to accomplish personalized drug testing within 2 wk after obtaining the tumor samples. The defined culture conditions and drug concentrations in the PTC model facilitate its clin. application in precision oncol. PTC tests of 59 patients with gastric, colorectal, or breast cancers revealed an overall accuracy of 93% in predicting their clin. outcomes. We implemented PTC to guide chemotherapy selection for a patient with mucinous rectal adenocarcinoma who experienced recurrence with metastases after conventional therapy. After three cycles of a nonconventional therapy identified by the PTC, the patient showed a pos. response. These findings need to be validated in larger clin. trials, but they suggest that the PTC model could be prospectively implemented in clin. decision-making for therapy selection.
Science Translational Medicine published new progress about Allele frequency. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts