Adding a certain compound to certain chemical reactions, such as: 111-90-0, Diethylene Glycol Monoethyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 111-90-0, blongs to alcohols-buliding-blocks compound. SDS of cas: 111-90-0
To a solution of 3 (0.5 g, 1.78 mmol), DMAP (0.22 g, 1.78 mmol), and diethylene glycol monoethyl ether (0.24 g, 1.78 mmol) in dichloromethane (15 mL) was added portionwise EDCI (0.34 g, 1.78 mmol) at room temperature. After stirring for 2 hrs, the product was extracted with ether (45 mL). The ether solution was washed with water (50 mL), a solution of 1N HCl (10 mL), and water (40 mL), dried over MgSO4, and concentrated. The residue was purified with silica gel column chromatography eluting with ethyl acetate to give compound 8 (0.18 g) as an oil in 25% yield. 1H NMR delta (CDCl3) 1.21 (3H, t, J = 6.9 Hz), 1.75 (6H, brs) 1.84 (2H, quint, J = 6.9 Hz), 1.95 (6H, brs), 2.05 (3H, brs), 2.38 (2H, t, J = 6.9 Hz), 3.18 (2H, q, J = 6.9 Hz), 3.53 (2H, q, , J = 6.9 Hz), 3.61 (2H, t, J = 6.9 Hz), 3.67 (2H, t, J = 6.9 Hz), 3.74 (2H, t, J = 6.9 Hz), 4.25 (2H, t, J = 6.9 Hz), 4.47 (1H, s), 4.62 (1H, s). LC-MS (ESI) m/z calcd for C21H36N2O5 [M + H]+ 397.26, found [M + H]+ 397.32.
The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kim, In-Hae; Nishi, Kosuke; Kasagami, Takeo; Morisseau, Christophe; Liu, Jun-Yan; Tsai, Hsing-Ju; Hammock, Bruce D.; Bioorganic and medicinal chemistry letters; vol. 22; 18; (2012); p. 5889 – 5892,4;,
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