In 2012,Roughley, Stephen D.; Browne, Helen; Macias, Alba T.; Benwell, Karen; Brooks, Teresa; D’Alessandro, Jalanie; Daniels, Zoe; Dugdale, Sarah; Francis, Geraint; Gibbons, Ben; Hart, Terance; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Matassova, Natalia; Mansell, Howard; Merrett, Angela; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Simmonite, Heather; Tan, Kiri; Walls, Steven B.; Wong, Melanie published 《Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity》.Bioorganic & Medicinal Chemistry Letters published the findings.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:
Attempts to optimize the human fatty acid amide hydrolase (FAAH) inhibition and physicochem. properties of previously reported tetrasubstituted azetidine urea FAAH inhibitor, VER-156084, are reported. The SAR of a series of analogs and in vivo dose-dependent FAAH inhibition in an anandamide-loading study in rats were determined The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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