In 2019,International Research Journal of Pharmacy included an article by Wadher, Sailesh J.; Supekar, Bhagwan B.; Shivpuje, Shivraj S.. Synthetic Route of C13H19Br2ClN2O. The article was titled 《Development and validation of new FT-IR spectrophotometric method for simultaneous estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined pharmaceutical solid tablet dosage form》. The information in the text is summarized as follows:
IR spectroscopy is also known as vibrational spectroscopy. FTIR is a non-destructive, highly sensitive, highly specific and robust anal. technique by which almost any solid, liquid or gas samples can be analyzed. The given research work is related with successful development and validation of newer, accurate, precise and sensitive FT-IR anal. method for estimation of cetirizine hydrochloride and ambroxol hydrochloride in their combined tablet dosage form. Literature survey reveals that, there is no FT-IR spectrophotometric method was developed and validated until now for this combination. KBr (Ar) grade was used as diluent. The functional groups were selected as AR-NH (1631 cm-1) for ambroxol HCl and C=O (1741 cm-1) for cetirizine HCl. The method was validated as per ICH guidelines. The linearity was developed at 6.0-36.0% weight/weight for AMB HCl and 0.5-3.0% weight/weight for CET HCl resp. The correlation coefficients were found to be 0.9993 and 0.9995 resp. The precision was found to be within acceptable limit. The developed method was found to be accurate and repeatable the % RSD was found to be within 2%. The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Synthetic Route of C13H19Br2ClN2O)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Synthetic Route of C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts