In 2017,Pilicer, Samantha L.; Bakhshi, Pegah R.; Bentley, Keith W.; Wolf, Christian published 《Biomimetic Chirality Sensing with Pyridoxal-5′-phosphate》.Journal of the American Chemical Society published the findings.Product Details of 126456-43-7 The information in the text is summarized as follows:
Pyridoxal-5′-phosphate (PLP) is introduced to a biomimetic indicator displacement assay for simultaneous determination of the absolute configuration, enantiomeric composition and concentration of unprotected amino acids, amino alcs. and amines. The chiroptical assay is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for CD and fluorescence sensing anal. The substrate binding yields characteristic Cotton effects that provide information about the target compound ee and the synchronous release of the indicator results in a nonenantioselective off-on fluorescence response that is independent of the enantiomeric sample composition and readily correlated to the total analyte concentration The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 126456-43-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts