Related Products of 153759-59-2On October 31, 2013 ,《Hybrid benzofuran-bisindole derivatives: New prototypes with promising anti-hyperlipidemic activities》 appeared in European Journal of Medicinal Chemistry. The author of the article were Sashidhara, Koneni V.; Modukuri, Ram K.; Sonkar, Ravi; Rao, K. Bhaskara; Bhatia, Gitika. The article conveys some information:
A series of different benzofuran-bisindole hybrids I [R = Me, Cl, t-Bu, etc.; R1 = Cl, MeO, NC; R3 = H, HO, MeO, O2N] were synthesized and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activity in triton WR-1339 induced hyperlipidemic rats. four compounds showed significant decrease in plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) followed by increase in postheparin lipolytic activity (PHLA). In addition, the active hybrids possessed moderate antioxidant properties and increased the plasma lecithin cholesterol acyltransferase (LCAT) activity, which plays a key role in lipoprotein metabolism contributing to an increased level of HDL-C in serum. These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2
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