Sashidhara, Koneni V.; Modukuri, Ram K.; Choudhary, Dharmendra; Bhaskara Rao, K.; Kumar, Manoj; Khedgikar, Vikram; Trivedi, Ritu published their research in European Journal of Medicinal Chemistry on December 31 ,2013. The article was titled 《Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporotic activities》.Electric Literature of C12H14O3 The article contains the following contents:
Anti-osteoporotic effects of the newly synthesized coumarin-pyridine hybrids were evaluated in primary cultures of rat calvarial osteoblasts in vitro. Four of these compounds were potent in stimulating osteoblast differentiation and mineralization as assessed by the alk. phosphatase production and alizarin red-S staining assay, resp. These compounds were also found to be nontoxic in osteoblast cells as compared to the control group in an MTT assay. Furthermore, the effect of these compounds on the transcript levels of osteogenic genes revealed that the compound I robustly enhanced mineralization of the osteogenic genes in calvarial osteoblasts. In this context, compound I was selected as a potential lead for further structural optimization in the development of new anti-osteoporotic agents. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Electric Literature of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
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