Sashidhara, Koneni V.; Palnati, Gopala Reddy; Sonkar, Ravi; Avula, Srinivasa Rao; Awasthi, Chetan; Bhatia, Gitika published an article in European Journal of Medicinal Chemistry. The title of the article was 《Coumarin chalcone fibrates: A new structural class of lipid lowering agents》.Computed Properties of C12H14O3 The author mentioned the following in the article:
In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% resp. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Computed Properties of C12H14O3)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Computed Properties of C12H14O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts