Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Vikas; Modukuri, Ram K.; Verma, Richa; Murthy, P. K. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi》.COA of Formula: C12H14O3 The author mentioned the following in the article:
Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. Among all the synthesized compounds, only two compounds, namely (E,E)-I (R = iPr, R1 = 2-furyl; R = tBu, R1 = 2-thienyl) were identified to be promising in vitro. These active compounds were tested in B. malayi-jird (Meriones unguiculatus) and B. malayi-Mastomys coucha models. Compound (E,E)-I (R = tBu, R1 = 2-thienyl) showed 100% embryostatic effect and 49% macrofilaricidal in jird and M. coucha models, resp. This study provides a new structural clue for the development of novel antifilarial lead mols. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.COA of Formula: C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
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