《Preparation and characterization of dry β-cyclodextrin-based ternary complexes of haloperidol and lactic acid for drug delivery》 was written by Chantasart, Doungdaw; Rakkaew, Prisada. SDS of cas: 54-17-1 And the article was included in Journal of Drug Delivery Science and Technology on August 31 ,2019. The article conveys some information:
This study was aimed to prepare dry β-cyclodextrin (β-CD)-based ternary complexes of haloperidol (HALO) with lactic acid for drug delivery. The influences of different media (buffers pH 3 and pH 6) and preparation methods ((freeze drying (FD) and solvent evaporation (SE)) on the HALO inclusion complexes were determined HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 exhibited higher inclusion yield than those in buffer pH 6. Furthermore, HALO/β-CD/lactic acid ternary complexes prepared via FD gave higher inclusion yield than those prepared via SE. The physicochem. properties of dry HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 were subsequently determined The interaction of HALO, β-CD and lactic acid was found and confirmed by Fourier transform IR and proton NMR. Results from differential scanning calorimetry and X-ray powder diffractometry depicted that the β-CD ternary complexes of HALO and lactic acid prepared via FD in buffer pH 3 transformed the drug from a crystalline state to an amorphous state. With significantly enhanced release of HALO from the complexes, HALO/β-CD/lactic acid ternary complexes was shown to be a promising carrier for HALO delivery. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1)
rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.SDS of cas: 54-17-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts