Fonseca-Santos, Bruno; Chorilli, Marlus published the artcile< The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems>, Synthetic Route of 501-36-0 , the main research area is review resveratrol neurol disease nanotechnol; Blood–brain barrier; Brain; Nanocarriers; Nanomedicines; Nasal drug delivery; Resveratrol.
A review. Neurol. disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biol. activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurol. disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnol.-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacol. and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clin. trials for some neurol. diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurol. diseases. Thus, the use of this nutraceutical has shown true for neurol. diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain.
International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Central nervous system agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .
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