The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(3-Fluorophenyl)ethanol
1 [0036] Aldehyde 14 can be prepared as shown in Scheme 3. 2-(3- Fluorophenyl)ethanol can be oxidized with Dess-Martin periodinane to give 15.Reductive amination with N-(2-hydroxyethyl)benzyl amine gives 16. Hydrogenolysis, Boc protection, and Dess-Martin oxidation gives 14 in excellent yields.Scheme 3. Synthesis of aldehyde 14 used in the synthesis of 1
With the rapid development of chemical substances, we look forward to future research findings about 52059-53-7.
Reference:
Patent; NORTHWESTERN UNIVERSITY; YANG, Sun; MEYSKENS, Frank, L.; SILVERMAN, Richard, B.; JI, Haitao; XUE, Fengtian; POULOS, Thomas, L.; WO2012/97121; (2012); A2;,
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