Barros, A. B.; Moura, A. F.; Silva, D. A.; Oliveira, T. M.; Barreto, F. S.; Ribeiro, W. L. C.; Alves, A. P. N. N.; Araujo, A. J.; Moraes Filho, M. O.; Iles, B.; Medeiros, J. V. R.; Marinho-Filho, J. D. B. published the artcile< Evaluation of antitumor potential of cashew gum extracted from Anacardium occidentale Linn>, Computed Properties of 492-62-6, the main research area is anacardium colorectal carcinoma cashew gum antitumor melanoma model; Antitumor activity; Melanoma model; Polysaccharide.
This study aims to determine the antitumor potential of cashew gum in vitro and in vivo. The cashew gum structure is similar to already showed in literature. The cytotoxicity effect of CG was performed by MTT assay, and B16-F10 melanoma model was used to evaluate antitumor effect. The tumor inhibition was calculated based on tumor weight Hematol., histopathol., FTIR, oxidative stress and Western Blot anal. were performed to elucidate the mechanism of inhibition and toxic effects. As results, CG did not demonstrate cytotoxicity in vitro, however showed a significant tumor inhibition in vivo, with about 36.9 to 43% of reduction in tumor mass, with no toxicity to organs. Animals treated with CG did not show toxicity in normal tissues, FTIR spectrum and oxidative stress anal. of the tumor tissue indicated that CG cause tumor inhibition with the presence of apoptosis morphotype cells, without alterations in the levels of antioxidants components. In addition, it was observed that CG reduced the expression of γH2AX without changing the expression of caspase-3. With this, we can suggest that this polymer can assist in the anticancer activity and/or decrease the side effects of standard drugs used in treatment of cancer.
International Journal of Biological Macromolecules published new progress about Anacardium occidentale. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.
Referemce:
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Alcohols – Chemistry LibreTexts